The purpose of this study was to evaluate the color difference of nanohybrid and ormocer-based composite resins with different thicknesses when 4 different shades of resin luting cement were used. 56 disc specimens of each composite resin (Aelite aesthetic enamel, Ceram-X mono) with 0.5 and 1 mm thicknesses were fabricated. Baseline color measurements were performed using a clinical spectrophotometer. The specimens of each thicknesses of each resin were randomly divided into 4 groups according to the shades of resin luting cement (white/A1, yellow/universal/A3, transparent and white opaque) (n = 7). Mixed resin cement was applied onto the resin specimens using a Teflon mold in 0.1 mm thickness. Color measurements of cemented composite resin specimens were repeated and color difference (∆E) between baseline and after cementation measurements was calculated. ANOVA and Tukey's test were used for statistical analysis. The opaque shade had significantly increased ∆E values as compared to the other shades (p < 0.05). For all shades except white opaque in both thicknesses, ∆E values of aelite aesthetic enamel were higher as compared to Ceram-X mono. There is no significant difference between 2 thicknesses for both resins in terms of ∆E values. The shade of resin cement and the type of the resin affected the final color; however, the thickness of composite resin had no influence on the final color of restoration. Selecting the shade of resin luting cement before cementation of indirect composite laminate restoration is important to achieve final color match.