Recurrence of Granular Corneal Dystrophy Type 1 After Phototherapeutic Keratectomy, Lamellar Keratoplasty, and Penetrating Keratoplasty in a Single Population. 2017

Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
*Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada; †Cornea Research Foundation of America, Indianapolis, IN; and ‡Price Vision Group, Indianapolis, IN.

OBJECTIVE To describe the recurrence of granular corneal dystrophy type 1 (GCD1) after penetrating keratoplasty (PKP), anterior lamellar keratoplasty (ALK), deep anterior lamellar keratoplasty (DALK), and phototherapeutic keratectomy (PTK) in a single population. The time required to achieve best-corrected visual acuity (BCVA) after each intervention was also analyzed. METHODS Retrospective review of all patients with GCD1 from a single center between 1989 and 2016. Surgical interventions were performed 50 times on 28 eyes of 15 patients. Data were primarily analyzed through Cox regression modeling with clustering and robust log-rank testing. RESULTS Significant recurrence occurred most rapidly after PTK (median time 2.7 years) and was most delayed after PKP (13.7 years). Significant recurrence occurred at a similar interval after ALK and DALK (3.7 and 3.2 years, respectively). Significant recurrence-free survival was longer for PKP than for ALK, DALK, or PTK (P = 0.04). The time required to obtain BCVA was shorter in the PTK group (median 1.8 months) than in the PKP and DALK groups (median 5.3 and 8.4 months, respectively; P = 0.03 and P = 0.02). All groups achieved a similar median BCVA (20/25-20/30). CONCLUSIONS This series indicates that GCD1 recurrence-free survival is longest after PKP with an associated delay in attaining BCVA. Conversely, PTK provided the fastest visual recovery with shorter recurrence-free survival.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D003317 Corneal Dystrophies, Hereditary Bilateral hereditary disorders of the cornea, usually autosomal dominant, which may be present at birth but more frequently develop during adolescence and progress slowly throughout life. Central macular dystrophy is transmitted as an autosomal recessive defect. Corneal Dystrophies,Granular Dystrophy, Corneal,Groenouw's Dystrophies,Macular Dystrophy, Corneal,Stromal Dystrophies, Corneal,Corneal Dystrophy,Corneal Dystrophy, Hereditary,Corneal Granular Dystrophies,Corneal Granular Dystrophy,Corneal Macular Dystrophies,Corneal Macular Dystrophy,Corneal Stromal Dystrophies,Corneal Stromal Dystrophy,Dystrophy, Corneal,Dystrophy, Corneal Granular,Dystrophy, Corneal Macular,Dystrophy, Corneal Stromal,Dystrophy, Hereditary Corneal,Groenouw Dystrophies,Groenouws Dystrophies,Hereditary Corneal Dystrophies,Hereditary Corneal Dystrophy,Stromal Dystrophy, Corneal
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D014792 Visual Acuity Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast. Acuities, Visual,Acuity, Visual,Visual Acuities

Related Publications

Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
September 2019, JAMA ophthalmology,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
January 2005, Journal of refractive surgery (Thorofare, N.J. : 1995),
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
November 2005, [Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
August 1995, Klinische Monatsblatter fur Augenheilkunde,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
March 1995, Klinische Monatsblatter fur Augenheilkunde,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
June 2003, Ophthalmology,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
November 1994, Ophthalmology,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
January 2005, Cornea,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
June 2015, Cornea,
Darrell R Lewis, and Marianne O Price, and Matthew T Feng, and Francis W Price
May 2024, American journal of ophthalmology,
Copied contents to your clipboard!