BIOMAT Database Logo BIOMAT Database Logo

Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconate. 1986

A J Baillie, and G H Coombs, and T F Dolan, and J Laurie

Liver and serum concentrations of antimony in the mouse have been determined after administration of sodium stibogluconate in the free, liposomal and niosomal form. High liver and low serum values were attained by the use of both vesicular formulations. Niosomal sodium stibogluconate was shown to be more active than free drug against experimental murine visceral leishmaniasis, an effect apparently dependent on maintaining high drug levels in the infected reticuloendothelial system.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D007893 Leishmania donovani A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). The sandfly genera Phlebotomus and Lutzomyia are the vectors. Leishmania (Leishmania) donovani,Leishmania leishmania donovani,Leishmania donovanus,Leishmania leishmania donovanus,donovani, Leishmania leishmania,donovanus, Leishmania,donovanus, Leishmania leishmania,leishmania donovanus, Leishmania
D007898 Leishmaniasis, Visceral A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African. Black Fever,Kala-Azar,Fever, Black,Kala Azar,Visceral Leishmaniasis
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008823 Micelles Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS. Micelle
D005942 Gluconates Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters. Copper Gluconate,Gluconate, Copper
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000965 Antimony A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.

Related Publications

A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery.
January 2019, Pharmaceutics,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid.
January 2013, Drug delivery,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
Osmotic behaviour of polyhedral non-ionic surfactant vesicles (niosomes).
June 1999, The Journal of pharmacy and pharmacology,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
The preparation and properties of niosomes--non-ionic surfactant vesicles.
December 1985, The Journal of pharmacy and pharmacology,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations.
March 2014, Drug delivery,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
An electron spin resonance study of non-ionic surfactant vesicles (niosomes).
July 2014, Chemistry and physics of lipids,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
Non-ionic surfactant based vesicles (niosomes) for non-invasive topical genetic immunization against hepatitis B.
May 2005, International journal of pharmaceutics,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
Non-ionic surfactant vesicles as a carrier system for dermal delivery of (+)-Catechin and their antioxidant effects.
March 2021, Journal of drug targeting,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications.
November 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,
A J Baillie, and G H Coombs, and T F Dolan, and J Laurie
Non-ionic Surfactant Based In Situ Forming Vesicles as Controlled Parenteral Delivery Systems.
April 2018, AAPS PharmSciTech,
Copied contents to your clipboard!