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Experimental and clinical studies suggest that somatostatin, a regulatory peptide widely distributed in human tissues may have electrophysiologic effects. We studied a group of 14 patients who underwent a complete electrophysiologic study for different rhythm disturbances. Somatostatin significantly increased the spontaneous cycle length, the atrial and atrioventricular nodal effective refractory periods, and the Wenckebach cycle length. The AH and HV intervals during sinus rhythm remained unchanged. The effectiveness of somatostatin to interrupt paroxysmal supraventricular tachycardias was assessed in 18 patients. Termination was obtained in 15 (82.5%). Our results show that somatostatin has a significant electrophysiologic effect on the human heart, and confirm its clinical effectiveness in some arrhythmias.
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
August 1982,
The Indian journal of medical research,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
June 1981,
International journal of clinical pharmacology, therapy, and toxicology,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
August 1985,
Archives des maladies du coeur et des vaisseaux,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
January 1978,
Therapie,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
November 1981,
Archives des maladies du coeur et des vaisseaux,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
January 1981,
Journal of cardiovascular pharmacology,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
January 1987,
The Canadian journal of cardiology,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
September 1978,
The American journal of cardiology,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
January 1979,
Acta chirurgica Scandinavica,
G Ghirlanda, and
P Santarelli, and
L Uccioli, and
S Sandric, and
F Bellocci, and
G Bianchini, and
P Cotroneo, and
A V Greco
January 1978,
Annales de l'anesthesiologie francaise,
