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SMS 201-995 is a new somatostatin analog which is 10-60 times more potent and specific than somatostatin as an inhibitor of GH and insulin release. The aim of this study was to assess its value as an adjunct to insulin therapy in insulin-dependent diabetic- (IDD) patients. Six IDD patients were studied. Their average insulin doses ranged from 22-46 U/day, and hemoglobin A1c levels varied between 6.5-11.5%. Two patients had background retinopathy and mild sensorimotor neuropathy. After 12 h of glucemic stabilization, the patients were kept normoglycemic by connecting them to the Biostator-GCIIS. The study entailed two parts in random order, in which standardised mixed meals were administered at 0800, 1400, and 2000 h with or without sc bolus injections of 50 micrograms SMS 201-995 immediately before meal ingestion. Plasma free insulin, C-peptide, GH, and glucagon were measured by RIA. Postprandial hyperglycemia was significantly diminished by SMS 201-995 after breakfast, lunch, and dinner. Insulin requirements, both total and 2-h postprandially, decreased significantly with a parallel reduction in free insulin levels. Postprandial glucagon levels also significantly decreased, but GH profiles were similar. In conclusion, the somatostatin analog SMS 201-995 has a potential value as an adjunct to insulin in the management of IDD patients.
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
April 1990,
Transplantation proceedings,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
July 1990,
International journal of clinical pharmacology, therapy, and toxicology,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
January 1990,
The Journal of experimental zoology. Supplement : published under auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
April 1995,
The International journal of neuroscience,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
December 1987,
European journal of pharmacology,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
December 1986,
Clinical endocrinology,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
April 1988,
Medicina clinica,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
December 1991,
Digestive diseases and sciences,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
February 1989,
Harefuah,
M S Rios, and
I Navascues, and
J Saban, and
A Ordoñez, and
F Sevilla, and
E Del Pozo
June 1989,
Journal of endocrinological investigation,
