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Fourteen acromegalic patients, half of whom had been unsuccessfully treated with surgery, radiotherapy, or bromocriptine, were given the somatostatin analogue SMS 201-995 parenterally as the sole therapeutic regimen after a single administration had demonstrated suppression of serum growth hormone (GH). An impressive and sustained clinical improvement was documented in all patients, including those in whom bromocriptine had failed; most marked was the decrease in soft tissue swelling and headache and an improved performance status. GH levels decreased each time SMS 201-995 was injected but returned to basal levels within 8 h in most of the patients. With chronic therapy, 24-h mean levels were significantly suppressed, and the GH stimulability of thyrotrophin-releasing hormone and growth-hormone-releasing hormone (pl-44) was markedly reduced. Discontinuation of SMS 201-995 therapy was associated with a return of symptoms and abnormal GH dynamics. The efficacy and safety of chronically administered SMS 201-995 in active acromegaly opens new horizons for its treatment.
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
February 1992,
Nihon Naibunpi Gakkai zasshi,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
December 1985,
The New England journal of medicine,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
May 1986,
The New England journal of medicine,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
January 1986,
Scandinavian journal of gastroenterology. Supplement,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
November 1988,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
January 1987,
Clinical endocrinology,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
October 1988,
Endocrinologia japonica,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
April 1987,
Postgraduate medical journal,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
April 1986,
Klinische Wochenschrift,
G Tolis, and
S Malachtari, and
A Mortoglou, and
G Rigas, and
C Saridakis, and
T Kamillaris, and
J Andreou, and
Y Kimpouris, and
E del Pozo, and
A Yotis
January 1988,
The Journal of clinical endocrinology and metabolism,
