-transparent.png){kind=logo}
Inappropriate hypersecretion of TSH was investigated in a 25 year old man whose hyperthyroidism had relapsed 4 years after subtotal thyroidectomy. Serum TSH levels were further increased by both TRH and metoclopramide and were partially suppressed by triiodothyronine (120 micrograms/day). The serum alpha-subunit: TSH molar ratio was less than 1.0, and computerised axial tomography showed no evidence of a pituitary tumour. These features are characteristic of inappropriate TSH secretion due to thyrotroph resistance to thyroid hormones. A long-acting somatostatin analogue (SMS 201-995), 50 micrograms injected sc twice-daily for three days, suppressed TSH levels and nearly normalised thyroid hormone levels. Somatostatin analogues may be therapeutically useful in thyrotoxicosis due to non-tumoural inappropriate TSH hypersecretion.
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
December 1989,
Scandinavian journal of gastroenterology,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
July 1987,
The Korean journal of internal medicine,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
January 1989,
The Journal of clinical endocrinology and metabolism,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
October 1988,
Endocrinologia japonica,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
June 1985,
Experientia,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
February 1989,
Harefuah,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
December 1986,
Annals of internal medicine,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
February 1992,
Alimentary pharmacology & therapeutics,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
January 1985,
The New England journal of medicine,
G Williams, and
M Kraenzlin, and
L Sandler, and
J Burrin, and
A Law, and
S Bloom, and
G F Joplin
May 1990,
Clinical endocrinology,
