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A total of 512 male rats were used to investigate the effects of H2-receptor antagonists on the liver after two-thirds hepatectomy or after carbon tetrachloride (CCl4)-induced hepatic injury. The serum aminotransferase levels in hepatectomy rats were significantly elevated as compared with those of rats with the sham operation 1 and 2 days after the operation. However, there were no differences in the serum aminotransferase levels and liver regeneration rates among the groups of hepatectomy rats who were treated with saline, cimetidine, or ranitidine. The injections of cimetidine or ranitidine did not induce a significant increase in serum amino-transferase levels or increase the severity of liver cell necrosis in CCl4-treated rats, as compared with the CCl4-treated rats who received saline injection. Thus, our data indicate that H2-receptor antagonists do not inhibit liver regeneration in rats after two-thirds hepatectomy or exert a detrimental effect on the liver cell necrosis in rats after CCl4-induced hepatic injury.
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
March 1961,
Gastroenterology,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
June 1983,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
January 1987,
Journal of biochemical toxicology,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
April 1994,
Proceedings of the National Science Council, Republic of China. Part B, Life sciences,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
August 1986,
Japanese journal of pharmacology,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
September 1957,
Rivista di patologia e clinica,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
January 1989,
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
October 1962,
Kiserletes orvostudomany,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
September 2004,
Transplantation proceedings,
S D Lee, and
J Y Wang, and
C H Cho, and
J C Wu, and
R H Lu, and
K H Lai, and
Y T Tsai, and
K J Lo
February 1984,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
