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A female child was admitted to the hospital few days after birth with severe hypoglycemia and convulsive episodes. Plasma insulin levels were elevated and oral and intravenous administration of glucose were unable to keep blood glucose above 2 mmol/l limit. Intravenous infusion of a long acting somatostatin analog, SMS 201-995, at a dosage gradually increasing from 2 to 50 micrograms/24 hr, was accompanied by a dramatic fall in circulating insulin levels. Normality of glucose homeostasis was restored and convulsive spells ceased. Fasting blood glucose levels stabilized between 3.4 and 4.7 mmol/l. No rebound phenomenon was observed during short term interruptions of the SMS 201-995 infusion. A subtotal pancreatectomy was performed during SMS treatment, and the diagnosis of nesidioblastosis was confirmed by immunocytologic and electron-microscopic studies. It is concluded that this new potent and long acting somatostatin derivative may be useful in the management of hyperinsulinism in the neonate.
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
January 1988,
The Journal of clinical endocrinology and metabolism,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
September 1990,
Journal of endocrinological investigation,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
October 1988,
Endocrinologia japonica,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
March 1989,
Digestive diseases and sciences,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
December 1989,
Scandinavian journal of gastroenterology,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
January 1988,
Hormone research,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
March 1988,
Zeitschrift fur Gastroenterologie,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
January 1990,
The Journal of experimental zoology. Supplement : published under auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
September 1989,
The Journal of clinical endocrinology and metabolism,
G J Bruining, and
A N Bosschaart, and
R S Aarsen, and
S W Lamberts, and
P J Sauer, and
E Del Pozo
December 1986,
Annals of internal medicine,
