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Long-acting somatostatin analogues may be of benefit in certain hypersecretory endocrine and gastrointestinal disorders. The 24 h hormonal and metabolic profiles of six normal male subjects receiving a twice daily subcutaneous injection of one such analogue SMS 201-995, 50 micrograms, has been compared to that obtained following placebo injection. Spontaneous daytime peaks of GH secretion were delayed until 1400 h following SMS 201-995 but nocturnal and total 24 h GH secretion were unaffected. The nocturnal rise in thyrotrophin was abolished by SMS 201-995 but thyroid function was unaffected. Insulin levels were suppressed following SMS 201-995 and the response to meals was inhibited. Glucose intolerance followed main meals. Glucagon levels were suppressed for up to 6 h. Circulating alanine levels were raised between 1200 h and 0600 h and there were intermittent elevations in lactate, pyruvate, glycerol and 3-hydroxybutyrate. Amino acid levels, including branched chain amino acids, were also increased. All six subjects suffered gastrointestinal side-effects. SMS 201-995, 50 micrograms, given twice daily shortly before meals does not suppress 24 h GH secretion, but demonstrates significant effects on metabolism and causes side effects in normal subjects.
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
June 1990,
The British journal of surgery,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
February 1989,
Harefuah,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
January 1986,
Scandinavian journal of gastroenterology. Supplement,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
November 1988,
Surgery,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
October 1996,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
April 1985,
Lancet (London, England),
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
December 1989,
Scandinavian journal of gastroenterology,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
January 1994,
G.E.N,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
April 1987,
Postgraduate medical journal,
R R Davies, and
M Miller, and
S J Turner, and
T H Goodship, and
D B Cook, and
M Watson, and
A McGill, and
H Orskov, and
K G Alberti, and
D G Johnston
January 1990,
Hormone research,
