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Two DNA markers, the met oncogene and the anonymous probe, pJ3.11, previously reported to be tightly linked to cystic fibrosis (CF), were used for linkage analysis in 26 families with two or more individuals affected with CF. A new high frequency polymorphism was identified using BanI and the pmetD probe. The results of linkage analysis were as follows: between met and CF, lod score of 18.2 at theta of .009; between pJ3.11 and CF, lod score of 12.1 at theta of 0; and between met and pJ3.11, lod score of 16.7 at theta of 0. These data indicate that most or all of CF is due to an abnormality at a single locus and that the DNA markers are useful for prenatal diagnosis and heterozygote detection within affected families.
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
December 1986,
American journal of human genetics,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
December 1986,
American journal of human genetics,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
December 1987,
Gene geography : a computerized bulletin on human gene frequencies,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
December 1989,
Journal de genetique humaine,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
October 1989,
American journal of human genetics,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
March 1990,
Human genetics,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
November 1987,
American journal of human genetics,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
December 1986,
American journal of human genetics,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
January 1991,
American journal of medical genetics,
J E Spence, and
C L Rosenbloom, and
W E O'Brien, and
D K Seilheimer, and
S Cole, and
R E Ferrell, and
R C Stern, and
A L Beaudet
July 1988,
American journal of human genetics,
