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The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dioxy 3, 4-benzyl-4-piperazine) a psychostimulant drug with mild dopaminomimetic activity. Both amphetamine and fipexide inhibited in vitro the release of ME-IR. The same effect was observed after in vivo acute administration and is also maintained after chronic treatment. The action of fipexide and amphetamine is still present after reserpine pretreatment. The results indicate that fipexide may facilitate dopamine neurotransmission by inhibition of an enkephalinergic inhibitory feed-back circuit.
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
February 1984,
Brain research,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
May 1986,
Neuroscience letters,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
June 1979,
European journal of pharmacology,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
January 1978,
Polish journal of pharmacology and pharmacy,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
February 1980,
European journal of pharmacology,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
March 1981,
European journal of pharmacology,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
April 1986,
Brain research,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
December 1993,
Pharmacology, biochemistry, and behavior,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
June 1991,
The Journal of pharmacology and experimental therapeutics,
L Lucchi, and
S Govoni, and
P F Spano, and
M Trabucchi
November 1983,
Brain research,
