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Lymphadenopathy-associated virus type 2 (HIV 2) was isolated from 3 patients with AIDS and 1 with AIDS-related complex. Clinical features were similar to those in patients infected with HIV 1. Viral isolates were characterised by hybridisation with HIV 1 and HIV 2 DNA probes. HIV 1 and HIV 2 serological studies were performed by enzyme-linked immunosorbent assay (ELISA), western blot, and radioimmunoprecipitation assay. HIV 2 IgG antibodies were detected in all sera. The molecular weights of the most representative HIV 2 proteins were determined by immunoblot. Cross-reactivity was restricted to HIV 1 and HIV 2 core proteins. In all 4 patients the neurotropism of HIV 2 was demonstrated by virus isolation from the cerebrospinal fluid and/or by evidence of intrathecal HIV 2 IgG synthesis. All sera were antibody negative by HIV 1 ELISA. An assay specific for HIV 2 is needed for screening of blood donations and for diagnosis and seroepidemiological study of HIV 2 infection.
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
November 1986,
The Journal of infectious diseases,
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
September 1984,
Lancet (London, England),
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
February 1987,
The American journal of surgical pathology,
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
February 1995,
AIDS research and human retroviruses,
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
July 1985,
The New England journal of medicine,
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
September 1984,
Lancet (London, England),
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
March 1985,
The New England journal of medicine,
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
April 1995,
Scottish medical journal,
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
December 1998,
Revue neurologique,
F Brun-Vezinet, and
M A Rey, and
C Katlama, and
P M Girard, and
D Roulot, and
P Yeni, and
L Lenoble, and
F Clavel, and
M Alizon, and
S Gadelle
October 2023,
Virus research,
