BIOMAT Database Logo BIOMAT Database Logo

MicroRNA mediated regulation of immunity against gram-negative bacteria. 2017

Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
a South Texas Center for Emerging Infectious Diseases and Center of Excellence in Infection Genomics , University of Texas at San Antonio , One UTSA Circle, San Antonio , TX.

Evidence over the last couple decades has comprehensively established that short, highly conserved, non-coding RNA species called microRNA (miRNA) exhibit the ability to regulate expression and function of host genes at the messenger RNA (mRNA) level. MicroRNAs play key regulatory roles in immune cell development, differentiation, and protective function. Intrinsic host immune response to invading pathogens rely on intricate orchestrated events in the development of innate and adaptive arms of immunity. We discuss the involvement of miRNAs in regulating these processes against gram negative pathogens in this review.

UI MeSH Term Description Entries
D007113 Immunity, Innate The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS. Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D006090 Gram-Negative Bacteria Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method. Gram Negative Bacteria
D006790 Host-Parasite Interactions The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically. Host-Parasite Relations,Parasite-Host Relations,Host-Parasite Relationship,Parasite-Host Interactions,Host Parasite Interactions,Host Parasite Relations,Host Parasite Relationship,Host-Parasite Interaction,Host-Parasite Relation,Host-Parasite Relationships,Interaction, Host-Parasite,Interaction, Parasite-Host,Interactions, Host-Parasite,Interactions, Parasite-Host,Parasite Host Interactions,Parasite Host Relations,Parasite-Host Interaction,Parasite-Host Relation,Relation, Host-Parasite,Relation, Parasite-Host,Relations, Host-Parasite,Relations, Parasite-Host,Relationship, Host-Parasite,Relationships, Host-Parasite
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016905 Gram-Negative Bacterial Infections Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method. Bacterial Infections, Gram-Negative,Infections, Gram-Negative Bacterial,Bacterial Infection, Gram-Negative,Gram Negative Bacterial Infections,Gram-Negative Bacterial Infection,Infection, Gram-Negative Bacterial
D056704 Adaptive Immunity Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE). Acquired Immunity,Hybrid Immunity,Adaptive Immune Response,Adoptive Immunity,Immunity, Adaptive,Hybrid Immunities,Immune Response, Adaptive,Immunity, Acquired,Immunity, Adoptive,Immunity, Hybrid,Response, Adaptive Immune
D056747 Immunomodulation Alteration of the immune system or of an immune response by agents that activate or suppress its function. This can include IMMUNIZATION or administration of immunomodulatory drugs. Immunomodulation can also encompass non-therapeutic alteration of the immune system effected by endogenous or exogenous substances. Immunomodulatory Therapy,Immunomodulations,Immunomodulatory Therapies,Therapies, Immunomodulatory,Therapy, Immunomodulatory
D035683 MicroRNAs Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing. RNA, Small Temporal,Small Temporal RNA,miRNA,stRNA,Micro RNA,MicroRNA,Primary MicroRNA,Primary miRNA,miRNAs,pre-miRNA,pri-miRNA,MicroRNA, Primary,RNA, Micro,Temporal RNA, Small,miRNA, Primary,pre miRNA,pri miRNA

Related Publications

Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.
August 2001, Immunity,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
N-acyl homoserinelactone-mediated gene regulation in gram-negative bacteria.
December 1999, Systematic and applied microbiology,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
Silencing gram-negative bacteria binding protein 1 decreases the immunity of Tribolium castaneum against bacteria.
April 2024, International journal of biological macromolecules,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
Suppression of cellular immunity by gram-negative bacteria.
January 1969, Antibiotica et chemotherapia. Fortschritte. Advances. Progres,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
[Activity of norfloxacin against gram-negative bacteria].
January 1989, La Tunisie medicale,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
[Activity of cefazolin against Gram-negative bacteria].
December 1978, Polski tygodnik lekarski (Warsaw, Poland : 1960),
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
Efflux-mediated multiresistance in Gram-negative bacteria.
January 2004, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
Immunity targeting common core antigens of gram-negative bacteria.
January 1990, Journal of veterinary internal medicine,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
Alternative drugs against multiresistant Gram-negative bacteria.
December 2020, Journal of global antimicrobial resistance,
Jonathon Keck, and Rishein Gupta, and Lane K Christenson, and Bernard P Arulanandam
[Vaccines against Gram-negative rod-shaped bacteria].
January 1983, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
Copied contents to your clipboard!