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Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine synthesis; the gene has previously been cloned and localised to the short arm of chromosome 11. Because of the interest in tyrosine hydroxylase as a candidate gene for manic-depressive psychosis and other affective disorders, we carried out family studies to determine the linkage of tyrosine hydroxylase with insulin, beta-globin, D11S12 and Harvey-ras 1, members of a linkage group which has previously been localised to 11p. Using DNA from the Centre d'Etude du Polymorphisme Humain (CEPH) and from two large British pedigrees, we show that tyrosine hydroxylase is closely linked to these four loci (z = 7.36, theta = 0.04 for linkage to insulin) and suggest a gene order based on multipoint mapping.
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
January 1986,
Genetic epidemiology. Supplement,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
May 1988,
Genomics,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
May 1991,
Neurology,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
September 1994,
Nature genetics,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
April 1994,
Journal of autism and developmental disorders,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
October 1990,
Lancet (London, England),
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
October 1995,
American journal of medical genetics,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
February 1981,
Journal de genetique humaine,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
September 1984,
FEBS letters,
P A Moss, and
K E Davies, and
C Boni, and
J Mallet, and
S T Reeders
February 1993,
Psychological medicine,
