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Two metabolites, isolated from the urine of rats given the cholinesterase reactivator HI-6 intravenously, still contained quaternary nitrogen atoms and therefore could not be extracted from aqueous solutions by organic solvents. Both metabolites were isolated by preparative high performance liquid chromatography and were identified using mass spectrometry, gas chromatography, infrared spectrometry, ultraviolet spectrometry and proton nuclear magnetic resonance spectrometry. The structures were confirmed by in-vitro preparation of the compounds. both metabolites contained 2-pyridone moieties. One had an intact pyridinium-aldoxime moiety, and therefore could still be therapeutically active. The excretion of unchanged HI-6 together with the two identified metabolites does not provide for a 100% mass balance, indicating that in the rat, other, as yet unidentified, metabolites must be formed.
D A Ligtenstein, and
E R Wils, and
S P Kossen, and
A G Hulst
January 1990,
Neurotoxicology and teratology,
D A Ligtenstein, and
E R Wils, and
S P Kossen, and
A G Hulst
January 1991,
Toxicology and applied pharmacology,
D A Ligtenstein, and
E R Wils, and
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A G Hulst
January 1988,
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D A Ligtenstein, and
E R Wils, and
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D A Ligtenstein, and
E R Wils, and
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November 1987,
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D A Ligtenstein, and
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A G Hulst
October 1974,
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D A Ligtenstein, and
E R Wils, and
S P Kossen, and
A G Hulst
June 1976,
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D A Ligtenstein, and
E R Wils, and
S P Kossen, and
A G Hulst
August 1973,
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D A Ligtenstein, and
E R Wils, and
S P Kossen, and
A G Hulst
March 1974,
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D A Ligtenstein, and
E R Wils, and
S P Kossen, and
A G Hulst
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