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The suggestion that the biological response to an oily intramuscular injection of testosterone ester is regulated by rapid accumulation of the steroid in body fat, followed by a slow release, has been tested by comparing the release rates of 14C-labelled testosterone propionate from different solvents following intramuscular injection into rats. Disappearance from the injection site was rectilinearly related to in-vitro partition coefficients, but elimination of radioactivity in urine and faeces was significantly longer, and the same for all four solvents. Testosterone and testosterone propionate were found in equal concentration in body fat, 2 and 3 days after injection, but their concentrations were too low to form an effective depot. It is suggested that the delay in release, and the independence of the delay on the nature of the solvent is a consequence of biliary recycling of testosterone.
M K Al-Hindawi, and
K C James, and
P J Nicholls
August 1976,
The Analyst,
M K Al-Hindawi, and
K C James, and
P J Nicholls
July 1983,
Steroids,
M K Al-Hindawi, and
K C James, and
P J Nicholls
June 1974,
Chemical & pharmaceutical bulletin,
M K Al-Hindawi, and
K C James, and
P J Nicholls
May 1979,
Developmental psychobiology,
M K Al-Hindawi, and
K C James, and
P J Nicholls
January 1981,
The Journal of pharmacy and pharmacology,
M K Al-Hindawi, and
K C James, and
P J Nicholls
April 1952,
Bollettino della Societa italiana di biologia sperimentale,
M K Al-Hindawi, and
K C James, and
P J Nicholls
April 1958,
The American journal of physiology,
M K Al-Hindawi, and
K C James, and
P J Nicholls
September 1948,
L'union medicale du Canada,
M K Al-Hindawi, and
K C James, and
P J Nicholls
January 1960,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
M K Al-Hindawi, and
K C James, and
P J Nicholls
May 1958,
Bollettino della Societa italiana di biologia sperimentale,
