Biomaterial Database

Aggressive angiomyxoma of the liver: a case report and literature review. 2017

Koki Sato, and Masahiro Ohira, and Seiichi Shimizu, and Shintarou Kuroda, and Kentaro Ide, and Kohei Ishiyama, and Tsuyoshi Kobayashi, and Hiroyuki Tahara, and Noriyuki Shiroma, and Koji Arihiro, and Michio Imamura, and Kazuaki Chayama, and Hideki Ohdan

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

BACKGROUND Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor that occurs almost exclusively in the soft tissue of the pelvis and perineum. AAM has both locally infiltrative and recurrent characteristics. Very few cases of AAM occurring outside of the pelvis and perineum have been reported. Here, we report a case of AAM originating in the liver of a 33-year-old female patient. METHODS A 33-year-old woman underwent S8 subsegmentectomy after clinical diagnosis of a mucinous cystic neoplasm of the liver. Histological analysis revealed a tumor composed of spindle-shaped cells with vascular proliferation in a myxoid stroma. Immunohistochemically, the tumor cells stained positively for CD34, estrogen receptor (ER), and progesterone receptor (PgR) and negatively for S-100, EMA, CK19, CD99, HMB45, and α-smooth muscle actin. The tumor was diagnosed as AAM originating from the liver. The patient received no adjuvant chemotherapy. No sign of recurrence or distant metastasis has been noted for 10 months after the surgery. CONCLUSIONS We here report a second case of AAM originating from the liver, which is an uncommon location for this particular tumor.