-transparent.png){kind=logo}
Antiarrhythmic effects of a new beta 1 selective adrenoceptor blocker, betaxolol, were examined in comparison with those of atenolol using two canine ventricular arrhythmia models (adrenaline arrhythmia and digitalis arrhythmia). Both betaxolol and atenolol suppressed adrenaline arrhythmia, and the minimum effective plasma concentration of betaxolol for this arrhythmia model was determined to be less than 10 ng/ml. However, on digitalis arrhythmia, both beta blockers were ineffective, even though the high doses used in these experiments, 3 mg/kg for betaxolol and 5 mg/kg for atenolol, showed significant hypotensive effects. The present results suggest that betaxolol and atenolol may be expected to be clinically effective on arrhythmias related to increased sympathetic tone.
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
August 1990,
Journal of clinical pharmacology,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
November 1992,
Japanese journal of pharmacology,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
January 1995,
Progress in cardiovascular diseases,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
May 1989,
Arzneimittel-Forschung,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
January 2017,
Kardiologia polska,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
August 1987,
Arzneimittel-Forschung,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
August 1986,
British journal of pharmacology,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
November 1993,
Japanese journal of pharmacology,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
September 1984,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Mitsuhashi, and
K Akiyama, and
K Hashimoto
June 1996,
European heart journal,
