Dose-ranging study of ivermectin in treatment of filariasis due to Wuchereria bancrofti. 1987

S Diallo, and M A Aziz, and O Ndir, and S Badiane, and I B Bah, and O Gaye

UI MeSH Term Description Entries
D007559 Ivermectin A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form. Eqvalan,Ivomec,MK-933,Mectizan,Stromectol,MK 933,MK933
D008297 Male Males
D008842 Microfilariae The prelarval stage of Filarioidea found in the blood and tissues of mammals, birds and intermediate hosts (vector). Microfilaria
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004605 Elephantiasis, Filarial Parasitic infestation of the human lymphatic system by WUCHERERIA BANCROFTI or BRUGIA MALAYI. It is also called lymphatic filariasis. Bancroftian Elephantiasis,Brugian Filariasis,Brugoa malayi Infection,Elephantiasis, Bancroftian,Filarial Elephantiasis,Filariasis, Lymphatic,Lymphatic Filariasis,Wuchereria bancrofti Infection,Bancroftian Filariasis,Elephantiasis, Malayi,Malayi Filariasis,Bancroftian Elephantiases,Bancroftian Filariases,Brugian Filariases,Brugoa malayi Infections,Filarial Elephantiases,Filariasis, Bancroftian,Filariasis, Brugian,Filariasis, Malayi,Infection, Brugoa malayi,Infection, Wuchereria bancrofti,Lymphatic Filariases,Malayi Elephantiases,Malayi Elephantiasis,Malayi Filariases,Wuchereria bancrofti Infections
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014958 Wuchereria bancrofti A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes. Filaria bancrofti,Filaria sanguinis hominis

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