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Cryo-EM Structures of Class B GPCR Reveal the Activation Mechanism. 2017

Felix Hausch
Clemens-Schöpf-Institute of Organic Chemistry and Biochemistry, Technical University Darmstadt, 64289, Darmstadt, Germany.

Caught in the act: Two-domain G-protein-coupled receptors of the class B family mediate peptide hormone signaling and play a pivotal role in diseases such as diabetes and obesity. Drug discovery for these GPCRs has been difficult, especially when agonists are needed. Now, the first structures of full-length active class B GPCRs have been solved, which illuminates the activation mechanism and could accelerate structure-based drug discovery for class B GPCRs.

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