-transparent.png){kind=logo}
The determination of a covalent binding of radioactive chemicals to DNA in intact mammalian organisms is proposed as a short-term test for carcinogenicity. The effectiveness of covalent binding to rat liver DNA correlates well with the hepatocarcinogenicity known from long-term bioassays. The binding indices range over more than five orders of magnitude between the strongest hepatocarcinogen aflatoxin B1 and the limit of detection of a binding with 100 muCi 14C-labelled chemical. The order of magnitude of binding is therefore a surprisingly good quantitative measure for carcinogenicity. The pattern of DNA binding sites is important especially for small alkylating agents where the determination of total binding might indicate a higher carcinogenic potency than is actually observed.
W K Lutz, and
C Schlatter
February 1984,
Carcinogenesis,
W K Lutz, and
C Schlatter
March 1990,
Environmental health perspectives,
W K Lutz, and
C Schlatter
December 1979,
Mutation research,
W K Lutz, and
C Schlatter
October 1999,
Environmental health perspectives,
W K Lutz, and
C Schlatter
January 1987,
Advances in veterinary science and comparative medicine,
W K Lutz, and
C Schlatter
October 1979,
Methods and findings in experimental and clinical pharmacology,
W K Lutz, and
C Schlatter
January 1989,
Research communications in chemical pathology and pharmacology,
W K Lutz, and
C Schlatter
January 1963,
Acta - Unio Internationalis Contra Cancrum,
W K Lutz, and
C Schlatter
January 1984,
Environmental mutagenesis,
W K Lutz, and
C Schlatter
March 1987,
Mutation research,
