-transparent.png){kind=logo}
A complete explanation of the neurotoxicity that follows kainic acid (KA) injection into the rat striatum is lacking. An assessment of the chronological course after intrastriatal KA injection of the activities of enzymes preferentially concentrated in glia or involved in the detoxification of oxygen metabolites is accomplished. An enhancement of the specific activities of glutathione peroxidase (GP) and catalase is found without an alteration in the specific activity of superoxide dismutase (SOD). There is no increase in the in vivo striatal levels of malondialdehyde, a putative indicator of lipid peroxidation, the expected result of cell membrane damage from oxygen metabolites. Understanding the mechanism and importance of the preferential induction of the activities of the detoxification enzymes will require further study.
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
November 1980,
Brain research,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
May 1980,
Journal of neuropathology and experimental neurology,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
February 1989,
Brain research,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
September 2002,
Journal of chemical neuroanatomy,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
June 1980,
Brain research,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
April 1980,
Methods and findings in experimental and clinical pharmacology,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
August 1978,
Life sciences,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
August 1980,
Journal of neurochemistry,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
July 1979,
Life sciences,
M R Cohen, and
C N Ramchand, and
V Sailer, and
M Fernandez, and
W McAmis, and
N Sridhara, and
C Alston
August 1978,
Neurochemical research,
