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A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents. 2017
Nikki L Sloan, and
Sajinder K Luthra, and
Graeme McRobbie, and
Sally L Pimlott, and
Andrew Sutherland
WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK. Andrew.Sutherland@glasgow.ac.uk.
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of 125I-labelled aryl compounds and SPECT radiotracers.
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