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The activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in norepinephrine synthesis, was determined in the mediobasal hypothalamus of adult male rats during acute and semistarvation. 3,4-Dihydroxyphenylalanine (DOPA) formed by TH was measured using high-performance liquid chromatography (HPLC). Acute starvation, as well as 3 weeks of semistarvation on a high-protein low-carbohydrate diet (CST PR) reduced TH activity significantly. Three weeks of a low-protein high-carbohydrate diet (CST KH) did not affect TH activity. While maximal velocity (Vmax) is significantly diminished in acute starvation and in semistarvation with a high-protein low-carbohydrate diet, Kd-values for tyrosine were not changed. These results suggest that TH activity in the brain contributes to decreased norepinephrine (NE) turnover in starvation.
E Philipp, and
K M Pirke
January 1977,
Brain research,
E Philipp, and
K M Pirke
September 1974,
Endocrinology,
E Philipp, and
K M Pirke
December 1973,
Endocrinology,
E Philipp, and
K M Pirke
January 1987,
Brain research bulletin,
E Philipp, and
K M Pirke
August 1989,
European journal of pharmacology,
E Philipp, and
K M Pirke
April 1982,
Neuropharmacology,
E Philipp, and
K M Pirke
September 1984,
Naunyn-Schmiedeberg's archives of pharmacology,
E Philipp, and
K M Pirke
December 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E Philipp, and
K M Pirke
July 1980,
Brain research,
E Philipp, and
K M Pirke
July 2004,
Wei sheng yan jiu = Journal of hygiene research,
