-transparent.png){kind=logo}
The effects of somatostatin on cholera toxin-induced secretory diarrhea and the appearance of glycoenzymes in the intestinal lumen and intestinal lymph were investigated in rat small intestine. After exposure to cholera toxin, marked fluid accumulation in the small intestinal tract and elevation of the jejunal mucosal cyclic AMP (cAMP) concentration were observed. The activity of alkaline phosphatase, aminopeptidase and sucrase increased in the intestinal lumen after toxin exposure. In intestinal lymph, alkaline phosphatase activity was increased after cholera toxin administration, while aminopeptidase activity remained unchanged. Somatostatin suppressed cholera toxin-induced secretory diarrhea, but it did not affect the elevated mucosal cAMP concentration. This peptide also inhibited the appearance of glycoenzymes in the intestinal lumen and lymph induced by cholera toxin administration. These results suggest that somatostatin exerts its inhibitory effects on cholera toxin-induced secretory diarrhea and on the appearance of glycoenzymes in the intestinal lumen and lymph by affecting processes beyond cAMP formation.
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
December 1993,
The American journal of physiology,
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
July 1979,
Gastroenterology,
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
May 1997,
Lancet (London, England),
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
November 1979,
Experientia,
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
June 1996,
The American journal of physiology,
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
January 1998,
Peptides,
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
January 2000,
Annals of the New York Academy of Sciences,
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
October 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
August 1993,
Acta physiologica Scandinavica,
M Yoshioka, and
H Asakura, and
Y Hamada, and
S Miura, and
K Kobayashi, and
T Morishita, and
A Morita, and
M Tsuchiya
August 1973,
Gastroenterology,
