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Adult athymic nude (BALB/c background) mice or inbred BALB/c mice were inoculated intraperitoneally with Hantaan virus (HV), and attempts were made to isolate the virus from brain, lung and spleen. Virus was isolated from the organs of BALB/c mice for only a short time after infection but was isolated from various organs of nude mice consistently for at least 84 days after infection. Viral antigen was also detected in various organs of nude mice for a long time after infection. The effects of adoptive transfer of immune serum or immune T cells from BALB/c to nude mice before or after virus inoculation were examined. Before transfer, the T cell fraction was treated with complement (C') (group 1), anti-L3T4 + C' (group 2), anti-Lyt1.2 + C' (group 3) or anti-Lyt2.2 + C' (group 4). When transferred before virus inoculation to test the effects on protection against infection, immune serum and T cells of groups 1, 2 and 4 were effective. When transferred after HV inoculation to test the effects on clearance of virus, group 1 was the most effective followed by group 2. These results suggest that humoral and cellular immunity both have roles in protection against HV infection, and that T cells possessing L3T4- Lyt2+ markers on the cell-surface are especially important for elimination of infectious virus in vivo.
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
April 1984,
Journal of virology,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
November 1995,
Journal of virology,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
September 1991,
The Journal of clinical investigation,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
July 1992,
Infection and immunity,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
June 1992,
Journal of virology,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
January 1987,
Thymus,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
April 1985,
The Journal of infectious diseases,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
June 1994,
Experimental hematology,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
October 2004,
Journal of virology,
H Asada, and
M Tamura, and
K Kondo, and
Y Okuno, and
Y Takahashi, and
Y Dohi, and
T Nagai, and
T Kurata, and
K Yamanishi
August 2013,
Current opinion in virology,
