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A radiolabelled 50-base oligonucleotide complementary with the measles virus gene encoding the nucleocapsid was used as a probe to identify persistent measles virus genome in the lymphocytes from patients with autoimmune chronic active hepatitis (AICAH). Positive hybrids were found in 12 of 18 patients, and correlated strongly with high antibody titres to measles. Among the 45 controls, positive hybrids were found in 1 patient with measles, 1 of 3 patients with systemic lupus erythematosus, and 2 of 4 patients with cryptogenic cirrhosis. Persistence of part of the measles virus genome in AICAH may have important implications in the pathogenesis of the liver disease, and possibly in other disorders such as systemic lupus erythematosus, multiple sclerosis, and Paget's disease where an abnormal immune response to measles has been observed.
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
January 1988,
Hepatology (Baltimore, Md.),
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
September 1989,
Lancet (London, England),
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
June 1989,
Lancet (London, England),
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
October 1993,
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
February 1993,
Therapeutische Umschau. Revue therapeutique,
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
March 1997,
Hong Kong medical journal = Xianggang yi xue za zhi,
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
June 1986,
Hospital practice (Office ed.),
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
January 1994,
Przeglad epidemiologiczny,
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
January 1987,
Gastroenterologie clinique et biologique,
D A Robertson, and
S L Zhang, and
E C Guy, and
R Wright
April 1992,
Gastroenterology,
