Biomaterial Database

Effects of dapiprazole on contractile responses of guinea pig isolated ileum. 1987

M D Lograno, and A Reibaldi, and D C Camerino

The effects of dapiprazole, a relatively new alpha 1-adrenolytic agent, on contractile responses and on spontaneous mechanical activity were studied in guinea pig isolated ileum. Dapiprazole (10(-10) to 10(-4) M) produced a concentration-dependent inhibition of high K+ (80 mM) -induced contractions. These inhibitory effects were observed with dapiprazole added either before or after the induced contractions. The Ca2+-induced contractions of K+-depolarized ileum were also inhibited by dapiprazole. Dapiprazole inhibited in a non competitive manner the responses of the ileum to: carbachol, histamine, 5-hydroxytryptamine, pentagastrin, angiotensin II and cholecystokinin. In order to analize whether dapiprazole exerts an intracellular effect on Ca2+-store, skinned preparations were used. The results suggest that dapiprazole might inhibit Ca2+ entry through both voltage-and receptor-operated channels of the smooth muscle membrane.

UI	MeSH Term	Description	Entries
D007082	Ileum	The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D008297	Male		Males
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009131	Muscle, Smooth, Vascular	The nonstriated involuntary muscle tissue of blood vessels.	Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002122	Calcium Chloride	A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.	Calcium Chloride Dihydrate,Calcium Chloride, Anhydrous
D005260	Female		Females
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia