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The concentrations of the excitatory amino acid, glutamate, the inhibitory amino acids, glycine and taurine, and the inactive amino acids, glutamine and alanine, were determined in cerebrospinal fluid samples from 12 neurological control and 17 chronic schizophrenic patients. No significant differences were observed in any amino acid between the study groups. Within the schizophrenic group, no differences were observed between paranoid and undifferentiated patients. The concentrations of these amino acids in samples obtained from six schizophrenic patients during drug-free as compared to haloperidol-treatment periods also did not differ. These results do not support the glutamate hypothesis of schizophrenia.
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
November 1978,
Archives of neurology,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
January 1988,
Journal of psychiatric research,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
February 1997,
Acta neurologica Scandinavica,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
January 1982,
Scandinavian journal of infectious diseases,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
August 1980,
Biological psychiatry,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
September 1981,
Journal of neurology, neurosurgery, and psychiatry,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
May 1958,
Neurology,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
August 1958,
A.M.A. archives of neurology and psychiatry,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
July 1981,
The Journal of pediatrics,
E R Korpi, and
C A Kaufmann, and
K M Marnela, and
D R Weinberger
August 1982,
No to shinkei = Brain and nerve,
