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The mutation for APKD has previously been localized to chromosome 16 by the demonstration of genetic linkage with both the alpha-chain of hemoglobin and phosphoglycolate phosphatase. These studies were carried out, however, on a limited number of families, and the possibility remained that mutations at other genetic loci might produce the disease. Such genetic heterogeneity of linkage would invalidate the general use of chromosome 16 markers for the purpose of detection of the disease and complicate the characterization of the APKD mutation at the molecular level. Therefore, further families were studied to resolve this issue. A total of 27 Northern European pedigrees were analyzed, all apparently unrelated and with origins in England, Scotland, Holland, and Eastern Finland. No evidence was found to suggest heterogeneity of genetic linkage between alpha-globin and the disease locus in this population.
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
January 1993,
Human genetics,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
December 1999,
Hong Kong medical journal = Xianggang yi xue za zhi,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
January 1994,
Yi chuan xue bao = Acta genetica Sinica,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
August 1988,
Lancet (London, England),
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
October 1988,
The New England journal of medicine,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
April 1995,
Human genetics,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
January 1992,
Contributions to nephrology,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
June 1995,
Human genetics,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
April 1990,
American journal of medical genetics,
S T Reeders, and
M H Breuning, and
M A Ryynanen, and
A F Wright, and
K E Davies, and
A W King, and
M L Watson, and
D J Weatherall
April 1982,
American journal of medical genetics,
