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1. The effect of pepsin on the loss of mucus glycoprotein from the gastric epithelial mucus layer was studied in the rat. 2. Pepsin was instilled into the gastric lumen, and luminal contents were subsequently assayed. 3. Glycoprotein loss increased with luminal pepsin, up to a concentration of 1 mg pepsin/ml. 4. Luminal glycoprotein had a molecular size distribution intermediate between subunit, and native mucus glycoprotein of the epithelial mucus layer. 5. Incubation of gastric epithelial scrapings with pepsin demonstrated that insoluble, native mucus glycoprotein was rapidly degraded to soluble glycoprotein of similar molecular size distribution to that found in vivo in the lumen.
D J Munster, and
P F Bagshaw, and
J G Wilson
May 1951,
Wiener klinische Wochenschrift,
D J Munster, and
P F Bagshaw, and
J G Wilson
January 1977,
Advances in experimental medicine and biology,
D J Munster, and
P F Bagshaw, and
J G Wilson
November 1932,
Canadian Medical Association journal,
D J Munster, and
P F Bagshaw, and
J G Wilson
January 1990,
Terapevticheskii arkhiv,
D J Munster, and
P F Bagshaw, and
J G Wilson
January 1985,
Digestion,
D J Munster, and
P F Bagshaw, and
J G Wilson
October 1946,
The New England journal of medicine,
D J Munster, and
P F Bagshaw, and
J G Wilson
January 1990,
Medicina (Florence, Italy),
D J Munster, and
P F Bagshaw, and
J G Wilson
January 1990,
Journal of internal medicine. Supplement,
D J Munster, and
P F Bagshaw, and
J G Wilson
June 1989,
The Journal of biological chemistry,
D J Munster, and
P F Bagshaw, and
J G Wilson
January 1982,
Advances in experimental medicine and biology,
