-transparent.png){kind=logo}
The effect of probenecid on the renal excretion of dyphylline was studied in chicken, rat and man. Dyphylline was found to be actively excreted when measured by the Sperber preparation in hens, the isolated perfused kidney of the rat and clearance studies in man. In each study probenecid significantly decreased dyphylline excretion demonstrating that dyphylline occupied the renal organic anion transport system. This same drug interaction, at the level of the renal excretory system, in these three species occurred at comparable concentrations of dyphylline and probenecid.
Related Publications
M Acara, and
E A Carr, and
E N Terry
March 1981,
The New England journal of medicine,
M Acara, and
E A Carr, and
E N Terry
December 1970,
Life sciences. Pt. 1: Physiology and pharmacology,
M Acara, and
E A Carr, and
E N Terry
January 1968,
Clinical pharmacology and therapeutics,
M Acara, and
E A Carr, and
E N Terry
February 1983,
Die Pharmazie,
M Acara, and
E A Carr, and
E N Terry
June 1983,
Clinical pharmacology and therapeutics,
M Acara, and
E A Carr, and
E N Terry
March 1976,
International journal of clinical pharmacology and biopharmacy,
M Acara, and
E A Carr, and
E N Terry
April 1953,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Acara, and
E A Carr, and
E N Terry
October 1969,
Lancet (London, England),
M Acara, and
E A Carr, and
E N Terry
October 1976,
Prostaglandins,
M Acara, and
E A Carr, and
E N Terry
September 1967,
Journal of pharmaceutical sciences,
