-transparent.png){kind=logo}
The cerebrospinal-fluid copper concentration, measured by electrothermal atomisation/atomic absorption spectrophotometry, was significantly higher in 24 patients with untreated, idiopathic Parkinson's disease than in a control population of 34 patients (p less than 0.001). The difference in the in-vitro capacity of copper to damage DNA, measured by the phenanthroline assay was even greater. The high phenanthroline-copper concentration correlated with disease severity (p = 0.02) and with the rate of progression of disease (p less than 0.05). A possible role is suggested for copper-catalysed oxidative mechanisms in the pathogenesis of Parkinson's disease.
Related Publications
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
August 1995,
Neuroreport,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
August 1999,
Journal of neurology, neurosurgery, and psychiatry,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
October 2004,
Movement disorders : official journal of the Movement Disorder Society,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
September 1998,
Archives of disease in childhood,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
January 1996,
Materia medica Polona. Polish journal of medicine and pharmacy,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
July 1993,
Annals of neurology,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
February 2024,
Clinica chimica acta; international journal of clinical chemistry,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
June 2010,
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
August 2005,
Life sciences,
H S Pall, and
A C Williams, and
D R Blake, and
J Lunec, and
J M Gutteridge, and
M Hall, and
A Taylor
January 2018,
PloS one,
