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Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. 2017
Yusuke Takahashi, and
Keishi Sugimachi, and
Ken Yamamoto, and
Atsushi Niida, and
Teppei Shimamura, and
Tetsuya Sato, and
Masahiko Watanabe, and
Junichi Tanaka, and
Shinei Kudo, and
Kenichi Sugihara, and
Kazuo Hase, and
Masato Kusunoki, and
Kazutaka Yamada, and
Yasuhiro Shimada, and
Yoshihiro Moriya, and
Yutaka Suzuki, and
Satoru Miyano, and
Masaki Mori, and
Koshi Mimori
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Genome-wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying single nucleotide polymorphisms (SNP) connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especially in the Japanese population, we performed a multi-stage genome-wide association study using a large number of samples: 1846 CRC cases and 2675 controls. We identified 4 SNP (rs7912831, rs4749812, rs7898455 and rs10905453) in chromosome region 10p14 associated with CRC; however, there are no coding or non-coding genes within this region of fairly extensive linkage disequilibrium (a 500-kb block) on 10p14. Our study revealed that the 10p14 locus is significantly correlated with susceptibility to CRC in the Japanese population, in accordance with the results of multiple studies in other races.
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