-transparent.png){kind=logo}
The cytotoxicities of sodium benzoate was studied using primary culture of hepatocytes established from adult rat liver by a collagenase perfusion technique and maintained as a monolayer in serum-free culture medium. The activities of ornithine transcarbamylase (as a marker of mitochondria) and tyrosine aminotransferase (as a marker of cytosol) were clearly suppressed by sodium benzoate at concentration in excess of 500 micrograms/ml. Intracellular protein synthesis and DNA synthesis were also suppressed, and the suppression of DNA synthesis was observed even with a lower concentration of benzoate (100 micrograms/ml).
Related Publications
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
June 2005,
Biochemical pharmacology,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
March 1978,
The American journal of physiology,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
January 1980,
Annals of the New York Academy of Sciences,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
August 1979,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
January 1982,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
January 1980,
Annals of the New York Academy of Sciences,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
January 1980,
Annals of the New York Academy of Sciences,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
July 1980,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
January 1988,
Cell biology international reports,
K Oyanagi, and
Y Kuniya, and
M Nagao, and
A Tsuchiyama, and
T Nakao
November 1982,
Cancer research,
