-transparent.png){kind=logo}
In digitonin-permeabilized bovine adrenal medullary cells, Ca2+ (0.1-1.0 microM) caused an activation of tyrosine hydroxylase which was dependent on the presence of ATP. This Ca2+-induced activation of the enzyme was observed even in the presence of optimal concentration of either cyclic AMP or 12-O-tetradecanoylphorbol-13-acetate (TPA) which by itself increased the enzyme activity. Calmodulin inhibitors, trifluoperazine (TFP) and N-(6-aminohexyl)-5-chloro-1-naphtalenesulfonamide (W-7), had little effect on the Ca2+-evoked activation of enzyme. These results suggest that micromolar concentrations of Ca2+ activate the activity of tyrosine hydroxylase probably through a Ca2+-dependent phosphorylation in digitonin-permeabilized adrenal medullary cells although the protein kinase(s) responsible for it still remains to be determined.
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
April 1983,
The Journal of biological chemistry,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
May 1986,
Proceedings of the National Academy of Sciences of the United States of America,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
August 1986,
Neuroscience letters,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
March 1988,
Cellular and molecular neurobiology,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
August 1990,
The Biochemical journal,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
July 1992,
Biochemical and biophysical research communications,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
September 1992,
The Journal of biological chemistry,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
March 1986,
Journal of neurochemistry,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
September 1991,
The Journal of biological chemistry,
N Yanagihara, and
Y Uezono, and
Y Koda, and
A Wada, and
F Izumi
December 1986,
The Journal of biological chemistry,
