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The in vitro effect of methylmercury (MM) on the enzymatic activities of brain cell specific marker enzymes, choline acetyltransferase (CAT), glutamic acid decarboxylase (GAD), 2',3'-cyclic nucleotide phosphohydrolase (CNP), glutamine synthetase (GS) and enolase was examined. The results demonstrate that at 100 microM MM, GS activity was not affected whereas a small decrease in the activity of both GAD (20%) and enolase (10%) was observed. CNP and CAT activity appeared to be more sensitive toward MM with 100 microM MM producing inhibition of 50% and 30%, respectively. The addition of sulfhydryl protecting reagents such as DTT or sodium thioglycolate can restore the enzyme activities to normal control levels despite prior exposure of the enzymes to MM.
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
October 1982,
Toxicology letters,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
September 1981,
Toxicology and applied pharmacology,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
December 1994,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
July 1989,
Toxicology and applied pharmacology,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
March 1992,
Journal of UOEH,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
January 1986,
Industrial health,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
March 1972,
Chemico-biological interactions,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
January 1979,
Folia medica Cracoviensia,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
January 1988,
Cellular and molecular biology,
M P Kung, and
P Kostyniak, and
J Olson, and
M Malone, and
J A Roth
September 1981,
Sangyo igaku. Japanese journal of industrial health,
