Biomaterial Database

Diphenylhydantoin induced gingival hyperplasia in ferrets: a precautionary note. 1979

P A Moore, and J W Smudski, and S Hopper

Diphenylhydantoin appears to modify the tissue response in ferrets to a gingival irritant. In the present study, ferrets were tested for the tissue response to a local irritant in their maxillary right quadrant, while their maxillary left quadrant was the control. A low incidence of hyperplasia was induced only in irritated gingival tissue of animals receiving DPH. The problems encountered in comparing the hyperplasia produced in ferrets and humans were also discussed.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010672	Phenytoin	An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.	Diphenylhydantoin,Fenitoin,Phenhydan,5,5-Diphenylhydantoin,5,5-diphenylimidazolidine-2,4-dione,Antisacer,Difenin,Dihydan,Dilantin,Epamin,Epanutin,Hydantol,Phenytoin Sodium,Sodium Diphenylhydantoinate,Diphenylhydantoinate, Sodium
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005289	Ferrets	Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.	Domestic Polecat,Domestic Polecats,European Polecat,European Polecats,Ferret,Mustela putorius,Mustela putorius furo,Polecat, Domestic,Polecat, European,Polecats, Domestic,Polecats, European
D005885	Gingival Hyperplasia	Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)	Gingival Hyperplasias,Hyperplasia, Gingival,Hyperplasias, Gingival
D005891	Gingivitis	Inflammation of gum tissue (GINGIVA) without loss of connective tissue.	Gingivitides
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia

Related Publications

P A Moore, and J W Smudski, and S Hopper

Antihistamines and diphenylhydantoin-induced gingival hyperplasia.

September 1958, The New England journal of medicine,

P A Moore, and J W Smudski, and S Hopper

Gingival hyperplasia induced by diphenylhydantoin in a gorilla.

November 1979, Journal of the American Veterinary Medical Association,

P A Moore, and J W Smudski, and S Hopper

Diphenylhydantoin gingival hyperplasia.

March 1969, American journal of diseases of children (1960),

P A Moore, and J W Smudski, and S Hopper

Folate treatment of diphenylhydantoin-induced gingival hyperplasia.

June 1989, Scandinavian journal of dental research,

P A Moore, and J W Smudski, and S Hopper

[Gingival hyperplasia and diphenylhydantoin].

January 1984, Parodontologia e stomatologia (nuova) : organo ufficiale dell'ARPA italiana, della Societa italiana Jonoforesi stomatologica e della Accademia ligustica di stomatologia,

P A Moore, and J W Smudski, and S Hopper

Gingival hyperplasia and diphenylhydantoin.

July 1972, Journal of periodontology,

P A Moore, and J W Smudski, and S Hopper

[Histopathological study on diphenylhydantoin gingival hyperplasia in rats, especially the role of gingival inflammation in diphenylhydantoin gingival hyperplasia].

September 1982, Nihon Shishubyo Gakkai kaishi,

P A Moore, and J W Smudski, and S Hopper

[Diphenylhydantoin gingival hyperplasia: ultrastructural study].

January 1988, Stomatologia mediterranea : SM,

P A Moore, and J W Smudski, and S Hopper

Incidence of diphenylhydantoin gingival hyperplasia.

December 1972, Oral surgery, oral medicine, and oral pathology,