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Simultaneous administration of cimetidine and many benzodiazepine anxiolytics has resulted in decreased body clearance and marked prolongation of the half-life of these agents. The pharmacokinetic interaction of buspirone, a new nonbenzodiazepine anxiolytic, and cimetidine was studied in 10 healthy male volunteers. Each received, in order, buspirone 45 mg/day (days 1-7), no drug (days 8-14), cimetidine 1 g/day (days 15-21), buspirone 45 mg/day plus cimetidine 1 g/day (days 22-28), and cimetidine 1 g/day (days 29-31). Buspirone and 1-pyrimidinyl piperazine (1-PP), an active metabolite, pharmacokinetics, urinary excretion of cimetidine, a manual dexterity test, the Stroop color-word interference test, and a visual analog mood scale were evaluated on each treatment. There were no significant (p greater than 0.05) differences among treatments for any measurement except for a slight (31%) but significant (p less than 0.05) increase in the 1-PP Cmax value. These results suggest that within the normal therapeutic dosage ranges for both drugs, it is unlikely that a clinically significant interaction between them will occur.
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
October 1983,
Acta neurologica Scandinavica,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
September 1985,
Clinical pharmacology and therapeutics,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
September 1985,
Clinical pharmacology and therapeutics,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
February 1994,
Pharmaceutical research,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
October 1996,
British journal of clinical pharmacology,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
October 1996,
Journal of clinical pharmacology,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
January 1988,
International journal of clinical pharmacology research,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
March 1993,
British journal of rheumatology,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
November 1990,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
R E Gammans, and
M Pfeffer, and
M L Westrick, and
H C Faulkner, and
K D Rehm, and
P J Goodson
November 1987,
Anesthesia and analgesia,
