-transparent.png){kind=logo}
The influence of varying the dietary protein content on the emergence of gamma-glutamyl transpeptidase (GGT)-positive foci in the livers of male rats fed elevated (2%) L-tryptophan (TRP) after being exposed to a hepatocarcinogen was investigated. Subtotal hepatectomies were performed, and 18 hr later the rats were treated with diethylnitrosamine (30 mg/kg). Ten days later four dietary groups were followed for 10 weeks: (1) control diet containing 21% protein (C); (2) control diet containing 5.3% protein (C-LP); (3) C + TRP; and (4) C-LP + TRP. Rats fed the C-LP diet developed heavier livers but fewer and smaller GGT + foci than did rats fed the C diet. Rats fed elevated TRP diets (C + TRP and C-LP + TRP) developed more and larger GGT + foci than did rats fed the regular control diets (C and C-LP), indicating that the promotional effect of elevated dietary TRP was similar at the two levels of dietary protein.
E Verney, and
D Wang, and
H Sidransky
April 1982,
Chemico-biological interactions,
E Verney, and
D Wang, and
H Sidransky
October 1981,
Gan,
E Verney, and
D Wang, and
H Sidransky
January 1982,
Research communications in chemical pathology and pharmacology,
E Verney, and
D Wang, and
H Sidransky
February 1988,
Cancer letters,
E Verney, and
D Wang, and
H Sidransky
April 1987,
Carcinogenesis,
E Verney, and
D Wang, and
H Sidransky
June 1973,
Medizinische Klinik,
E Verney, and
D Wang, and
H Sidransky
October 1971,
Lancet (London, England),
E Verney, and
D Wang, and
H Sidransky
May 1984,
Cancer research,
E Verney, and
D Wang, and
H Sidransky
December 1983,
Gan,
E Verney, and
D Wang, and
H Sidransky
April 1983,
Environmental health perspectives,
