| D008345 |
Manganese |
A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
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| D008664 |
Metal Metabolism, Inborn Errors |
Dysfunctions in the metabolism of metals resulting from inborn genetic mutations that are inherited or acquired in utero. |
Metal Metabolism, Inborn Error |
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| D003677 |
Deficiency Diseases |
A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed) |
Deficiency Disease,Disease, Deficiency,Diseases, Deficiency |
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| D006801 |
Humans |
Members of the species Homo sapiens. |
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man |
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| D000075703 |
Zinc Transporter 8 |
A zinc efflux transporter highly expressed by ISLET CELLS of the pancreas. It functions in the accumulation of zinc in intracellular vesicles and may be involved in INSULIN maturation and storage processes. Variations in the SLC30A8 gene are associated with susceptibility to DIABETES MELLITUS, TYPE 2. |
Slc30A8 Protein,Solute Carrier Family 30 Member 8 Protein,ZnT-8 Protein,ZnT 8 Protein |
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| D015032 |
Zinc |
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
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| D020149 |
Manganese Poisoning |
Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213) |
Nervous System Diseases, Manganese-Induced,Nervous System Poisoning, Manganese,Neurotoxicity Syndrome, Manganese,Poisoning, Manganese,Manganese Neurotoxicity Syndrome,Manganese Neurotoxicity Syndromes,Nervous System Diseases, Manganese Induced,Neurotoxicity Syndromes, Manganese,Syndrome, Manganese Neurotoxicity,Syndromes, Manganese Neurotoxicity |
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| D027682 |
Cation Transport Proteins |
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane. |
Cation Pumps,Cation Pump,Pump, Cation,Pumps, Cation |
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