BIOMAT Database Logo BIOMAT Database Logo

Antiallergic action of TMK-777, a leukotriene biosynthesis inhibitor. 1987

T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Research and Development Division, Terumo Corporation, Tokyo, Japan.

UI MeSH Term Description Entries
D006967 Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. Allergy,Allergic Reaction,Allergic Reactions,Allergies,Hypersensitivities,Reaction, Allergic,Reactions, Allergic
D010880 Piperidines A family of hexahydropyridines.
D006634 Histamine H1 Antagonists Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. Antihistamines, Classical,Antihistaminics, Classical,Antihistaminics, H1,Histamine H1 Antagonist,Histamine H1 Receptor Antagonist,Histamine H1 Receptor Antagonists,Histamine H1 Receptor Blockaders,Antagonists, Histamine H1,Antagonists, Histamine H1 Receptor,Antihistamines, Sedating,Blockaders, Histamine H1 Receptor,First Generation H1 Antagonists,H1 Receptor Blockaders,Histamine H1 Blockers,Receptor Blockaders, H1,Antagonist, Histamine H1,Classical Antihistamines,Classical Antihistaminics,H1 Antagonist, Histamine,H1 Antagonists, Histamine,H1 Antihistaminics,Sedating Antihistamines
D000707 Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death. Anaphylactic Reaction,Anaphylactoid Reaction,Anaphylactoid Shock,Shock, Anaphylactic,Anaphylactic Reactions,Anaphylactic Shock,Anaphylactoid Reactions,Reaction, Anaphylactic,Reaction, Anaphylactoid,Shock, Anaphylactoid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001183 Arthus Reaction A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis. Arthus Phenomenon,Phenomenon, Arthus,Reaction, Arthus
D016859 Lipoxygenase Inhibitors Compounds that bind to and inhibit that enzymatic activity of LIPOXYGENASES. Included under this category are inhibitors that are specific for lipoxygenase subtypes and act to reduce the production of LEUKOTRIENES. 5-Lipoxygenase Inhibitor,Lipoxygenase Inhibitor,12-Lipoxygenase Inhibitors,15-Lipoxygenase Inhibitors,5-Lipoxygenase Inhibitors,Arachidonate 12-Lipoxygenase Inhibitors,Arachidonate 15-Lipoxygenase Inhibitors,Arachidonate 5-Lipoxygenase Inhibitors,Inhibitors, Lipoxygenase,12 Lipoxygenase Inhibitors,12-Lipoxygenase Inhibitors, Arachidonate,15 Lipoxygenase Inhibitors,15-Lipoxygenase Inhibitors, Arachidonate,5 Lipoxygenase Inhibitor,5 Lipoxygenase Inhibitors,5-Lipoxygenase Inhibitors, Arachidonate,Arachidonate 12 Lipoxygenase Inhibitors,Arachidonate 15 Lipoxygenase Inhibitors,Arachidonate 5 Lipoxygenase Inhibitors,Inhibitor, 5-Lipoxygenase,Inhibitor, Lipoxygenase,Inhibitors, 12-Lipoxygenase,Inhibitors, 15-Lipoxygenase,Inhibitors, 5-Lipoxygenase,Inhibitors, Arachidonate 12-Lipoxygenase,Inhibitors, Arachidonate 15-Lipoxygenase,Inhibitors, Arachidonate 5-Lipoxygenase

Related Publications

T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Antiallergic action of inhibitors of leukotriene biosynthesis.
January 1985, Advances in prostaglandin, thromboxane, and leukotriene research,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Azelastine--a novel in vivo inhibitor of leukotriene biosynthesis: a possible mechanism of action: a mini review.
January 1995, The Journal of asthma : official journal of the Association for the Care of Asthma,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Caffeic acid is a selective inhibitor for leukotriene biosynthesis.
January 1984, Biochimica et biophysica acta,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.
February 2013, Chemical research in toxicology,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase.
May 2010, Cancer letters,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Characterization of A-93178, an iminoxy-quinoline inhibitor of leukotriene biosynthesis.
January 1997, Advances in experimental medicine and biology,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
A new class of leukotriene biosynthesis inhibitor: the development of MK-0591.
January 1993, Journal of lipid mediators,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Action of cyclooxygenase inhibitors and a leukotriene biosynthesis inhibitor on cisplatin-induced acute and delayed emesis in the ferret.
February 2007, Journal of pharmacological sciences,
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Antiasthmatic effects of a leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs.
February 1995, Journal of applied physiology (Bethesda, Md. : 1985),
T Wakabayashi, and S Ozawa, and J Arai, and M Takai, and Y Koshihara, and S Murota
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis.
June 1983, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!