Biomaterial Database

Coupling progenitor and neuronal diversity in the developing neocortex. 2017

Subashika Govindan, and Denis Jabaudon

Department of Basic Neuroscience, University of Geneva, Switzerland.

The adult neocortex is composed of several types of glutamatergic neurons, which are sequentially born from progenitors during development. The extent and nature of progenitor diversity, and how it relates to neuronal diversity, is still poorly understood. In this review, we discuss key features of neocortical progenitors across several species, including their morphological properties, cell cycling behaviour and molecular signatures, and how these features relate to the competence of these cells to generate distinct types of progenies.

UI	MeSH Term	Description	Entries
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002454	Cell Differentiation	Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.	Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D055495	Neurogenesis	Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.	Neurogeneses
D058953	Neural Stem Cells	Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.	Cell, Neural Stem,Cells, Neural Stem,Neural Stem Cell,Stem Cell, Neural,Stem Cells, Neural
D019070	Cell Lineage	The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.	Cell Lineages,Lineage, Cell,Lineages, Cell
D019579	Neocortex	The largest portion of the CEREBRAL CORTEX in which the NEURONS are arranged in six layers in the mammalian brain: molecular, external granular, external pyramidal, internal granular, internal pyramidal and multiform layers.	Cerebral Neocortex,External Granular Layer,Isocortex,Neocortical External Granular Layer,Neocortical External Pyramidal Layer,Neocortical Internal Granular Layer,Neocortical Internal Pyramidal Layer,Neocortical Molecular Layer,Neocortical Multiform Layer,Neopallial Cortex,Neopallium,Substantia Corticalis,Cerebral Neocortices,Cortex, Neopallial,Corticali, Substantia,Corticalis, Substantia,Cortices, Neopallial,External Granular Layers,Granular Layer, External,Granular Layers, External,Isocortices,Layer, External Granular,Layer, Neocortical Molecular,Layer, Neocortical Multiform,Layers, External Granular,Layers, Neocortical Molecular,Layers, Neocortical Multiform,Molecular Layer, Neocortical,Molecular Layers, Neocortical,Multiform Layer, Neocortical,Multiform Layers, Neocortical,Neocortex, Cerebral,Neocortical Molecular Layers,Neocortical Multiform Layers,Neocortices,Neocortices, Cerebral,Neopallial Cortices,Neopalliums,Substantia Corticali