BIOMAT Database Logo BIOMAT Database Logo

Skeletal Muscle Atrophy and Degeneration in a Mouse Model of Traumatic Brain Injury. 2018

Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
1 Department of Orthopedic Surgery, University of California , San Diego, California.

Atrophy is thought to be a primary mode of muscle loss in neuromuscular injuries. The differential effects of central and peripheral injuries on atrophy and degeneration/regeneration in skeletal muscle tissue have not been well described. This study investigated skeletal muscle atrophy and degeneration/regeneration in an animal model of traumatic brain injury (TBI). Eight 8-month-old wild-type C57BL6 mice underwent either a sham craniotomy or TBI targeting the motor cortex. Atrophy (fiber area; FA) and degeneration/regeneration (centralized nuclei proportions; CN) of the soleus and tibialis anterior (TA) muscles were measured 2 months post-injury. Injured soleus FAs were smaller than sham soleus (p = 0.02) and injured TA (p < 0.001). Mean CNs were higher in the TBI-injured TA than in other muscles. Differential TBI-induced atrophy and degeneration/regeneration in lower limb muscles suggests that muscle responses to cortical injury involve more complex changes than those observed with simple disuse atrophy.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009133 Muscular Atrophy Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation. Atrophy, Muscle,Neurogenic Muscular Atrophy,Neurotrophic Muscular Atrophy,Atrophies, Muscle,Atrophies, Muscular,Atrophies, Neurogenic Muscular,Atrophies, Neurotrophic Muscular,Atrophy, Muscular,Atrophy, Neurogenic Muscular,Atrophy, Neurotrophic Muscular,Muscle Atrophies,Muscle Atrophy,Muscular Atrophies,Muscular Atrophies, Neurogenic,Muscular Atrophies, Neurotrophic,Muscular Atrophy, Neurogenic,Muscular Atrophy, Neurotrophic,Neurogenic Muscular Atrophies,Neurotrophic Muscular Atrophies
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000070642 Brain Injuries, Traumatic A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain. Trauma, Brain,Traumatic Brain Injury,Encephalopathy, Traumatic,Injury, Brain, Traumatic,TBI (Traumatic Brain Injury),TBIs (Traumatic Brain Injuries),Traumatic Encephalopathy,Brain Injury, Traumatic,Brain Trauma,Brain Traumas,Encephalopathies, Traumatic,TBI (Traumatic Brain Injuries),Traumas, Brain,Traumatic Brain Injuries,Traumatic Encephalopathies
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018482 Muscle, Skeletal A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles. Anterior Tibial Muscle,Gastrocnemius Muscle,Muscle, Voluntary,Plantaris Muscle,Skeletal Muscle,Soleus Muscle,Muscle, Anterior Tibial,Muscle, Gastrocnemius,Muscle, Plantaris,Muscle, Soleus,Muscles, Skeletal,Muscles, Voluntary,Skeletal Muscles,Tibial Muscle, Anterior,Voluntary Muscle,Voluntary Muscles

Related Publications

Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
A novel simple traumatic brain injury mouse model.
April 2022, Chinese neurosurgical journal,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
Skeletal muscle atrophy in bioengineered skeletal muscle: a new model system.
October 2013, Tissue engineering. Part A,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
Molecular mechanisms of skeletal muscle atrophy in a mouse model of cerebral ischemia.
June 2015, Stroke,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model.
March 2024, Current molecular medicine,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
Skeletal Muscle Injury by Electroporation: A Model to Study Degeneration/Regeneration Pathways in Muscle.
January 2020, Methods in molecular biology (Clifton, N.J.),
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
New mouse model of skeletal muscle atrophy using spiral wire immobilization.
October 2016, Muscle & nerve,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
A mouse model of blast-induced mild traumatic brain injury.
December 2011, Experimental neurology,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
A mouse model of human repetitive mild traumatic brain injury.
January 2012, Journal of neuroscience methods,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury.
June 2017, Journal of visualized experiments : JoVE,
Bahar Shahidi, and Sameer B Shah, and Mary Esparza, and Brian P Head, and Samuel R Ward
Cosyntropin Attenuates Neuroinflammation in a Mouse Model of Traumatic Brain Injury.
January 2020, Frontiers in molecular neuroscience,
Copied contents to your clipboard!