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The effect of a two hour period of hypo- and hyperglucagonemia on a subsequent insulin-induced hypoglycemia was studied in nine healthy volunteers. Hypoglucagonemia was provoked by somatostatin (50 micrograms/h) and hyperglucagonemia by glucagon infusion (3.25 ng/kg/min) together with somatostatin, while saline alone was given as control. Hypoglycemia was induced by insulin infusion (2.4 U/h) for two hours. The hyperglycemic effect of glucagon was transient and similar nadir glucose levels were obtained in the three experiments. Preinfusion with glucagon impaired glucose recovery in spite of preserved secretion of epinephrine during restitution of blood glucose in this experiment. It is concluded, that a period of elevated glucagon levels deteriorates the restitution of blood glucose following hypoglycemia. Hyperglucagonemia, commonly apparent in poorly controlled diabetics, may therefore be of importance in explaining the impaired recovery of blood glucose seen in such patients after hypoglycemia.
N Clausen, and
U Adamson, and
P E Lins
October 1984,
The Journal of clinical endocrinology and metabolism,
N Clausen, and
U Adamson, and
P E Lins
January 1990,
Clinical physiology and biochemistry,
N Clausen, and
U Adamson, and
P E Lins
January 1994,
European journal of clinical pharmacology,
N Clausen, and
U Adamson, and
P E Lins
July 1983,
The Journal of clinical endocrinology and metabolism,
N Clausen, and
U Adamson, and
P E Lins
April 1979,
The American journal of physiology,
N Clausen, and
U Adamson, and
P E Lins
January 1981,
Acta diabetologica latina,
N Clausen, and
U Adamson, and
P E Lins
October 1988,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
N Clausen, and
U Adamson, and
P E Lins
October 1984,
The Western journal of medicine,
N Clausen, and
U Adamson, and
P E Lins
August 1994,
Metabolism: clinical and experimental,
N Clausen, and
U Adamson, and
P E Lins
December 1987,
The Journal of clinical endocrinology and metabolism,
