-transparent.png){kind=logo}
The long-term effects of excitotoxic lesions in the nucleus basalis magnocellularis of the rat were found to mimic several neuropathological and chemical changes associated with Alzheimer's disease. Neuritic plaque-like structures, neurofibrillary changes, and neuronal atrophy or loss were observed in the frontoparietal cortex, hippocampus, amygdala, and entorhinal cortex 14 months after the lesions were made. Cholinergic markers in neocortex were reduced, while catecholamine and indoleamine metabolism was largely unaffected at this time. Bilateral lesions of the nucleus basalis magnocellularis increased somatostatin and neuropeptide Y in the cortex of the rat by at least 138 and 284 percent, respectively, suggesting a functional interaction between cholinergic and peptidergic neurons that may differ from that in Alzheimer's disease.
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
January 1985,
Neurobiology of aging,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
April 1993,
Brain research,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
January 1988,
Neuroscience,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
January 1985,
Neurobiology of aging,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
September 2013,
European archives of psychiatry and clinical neuroscience,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
January 1996,
Restorative neurology and neuroscience,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
April 1991,
Brain research bulletin,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
July 1990,
Brain research bulletin,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
January 1986,
Progress in neuro-psychopharmacology & biological psychiatry,
G W Arendash, and
W J Millard, and
A J Dunn, and
E M Meyer
May 1993,
Pharmacology, biochemistry, and behavior,
