Biomaterial Database

Atypical acinar cell lesions of the pancreas in mice induced by 4-hydroxyaminoquinoline-1-oxide. 1987

M S Rao, and V Subbarao, and D G Scarpelli

Department of Pathology, Northwestern University Medical School, Chicago, IL 60611.

The carcinogenic effect of 4-hydroxyaminoquinoline-1-oxide (4-HAQO) on exocrine pancreas of mice after a single intravenous (i.v.) injection was investigated. At a dose of 24 mg/kg body weight, 100% of the mice killed at the end of 40 weeks had developed atypical acinar cell foci (AAF) in the pancreas. Each pancreas contained an average of 18.3 +/- 2.7 AAF. Cells in AAF were arranged as acini and their cytoplasm contained eosinophilic zymogen granules. The nuclei were large, round to oval, basally located and contained 1-2 prominent nucleoli. Cells in AAF showed a markedly increased mitotic activity with an index of 4 +/- 0.7/1000 cells as compared to a value of 0.25 +/- 0.25 in the acinar cell population of control pancreas. Autoradiographic studies showed a labeling index of 23 +/- 3 in AAF as compared to only 1.5 +/- 0.29 in the pancreatic acinar cells of controls. These findings indicate that 4-HAQO induces pancreatic lesions in mice which are quite similar to the acidophilic foci observed in rat pancreas and may serve as another useful model for studies of pancreatic carcinogenesis.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008938	Mitosis	A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.	M Phase, Mitotic,Mitotic M Phase,M Phases, Mitotic,Mitoses,Mitotic M Phases,Phase, Mitotic M,Phases, Mitotic M
D010179	Pancreas	A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010182	Pancreatic Diseases	Pathological processes of the PANCREAS.	Disease, Pancreatic,Diseases, Pancreatic,Pancreatic Disease
D002467	Cell Nucleus	Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D005723	gamma-Glutamyltransferase	An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.	GGTP,Glutamyl Transpeptidase,gammaglutamyltransferase,gamma-Glutamyl Transpeptidase,Transpeptidase, Glutamyl,Transpeptidase, gamma-Glutamyl,gamma Glutamyl Transpeptidase,gamma Glutamyltransferase
D000634	Aminoquinolines	Quinolines substituted in any position by one or more amino groups.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015108	4-Hydroxyaminoquinoline-1-oxide	A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.	4-Hydroxyaminoquinoline-N-oxide,4 Hydroxyaminoquinoline 1 oxide,4 Hydroxyaminoquinoline N oxide
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus