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Receptors for somatostatin (SOM) were identified on mouse bone marrow derived mast cells (MBMMC) and shown to vary in expression with the state of proliferation and differentiation of the MBMMC. Flow cytometric studies of the binding of fluorescein-labeled SOM and concurrent analyses of the binding of [125I]SOM demonstrated that the population of MBMMC capable of recognizing SOM specifically is that exhibiting a proliferative response to interleukin-3. The MBMMC that bound SOM reached a maximal number at 72 hr following the addition of interleukin-3, and were distributed principally in the G2/M phase of the cell cycle. SOM did not influence directly the proliferative responses of MBMMC to interleukin-3. The level of expression of SOM receptors thus may reflect the state of differentiation of mast cells, as well as determining the functional sensitivity to the inhibitory effects of SOM.
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
August 1995,
International archives of allergy and immunology,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
April 1994,
European journal of immunology,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
November 2012,
Experimental cell research,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
September 1993,
Blood,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
September 1986,
The Journal of allergy and clinical immunology,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
February 2000,
FEBS letters,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
January 1987,
Journal of immunology (Baltimore, Md. : 1950),
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
January 1990,
European journal of immunology,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
September 1990,
Experimental hematology,
F K Renold, and
P Dazin, and
E J Goetzl, and
D G Payan
August 1984,
Journal of immunology (Baltimore, Md. : 1950),
