-transparent.png){kind=logo}
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. Recent molecular genetic studies have indicated that amyloid protein is encoded as part of a larger protein by a gene on human chromosome 21 (refs 6-9). The amyloid protein precursor (APP) gene is expressed in brain and in several peripheral tissues, but the specific biochemical events leading to deposition of amyloid are not known. We have now screened complementary DNA libraries constructed from peripheral tissues to determine whether the messenger RNA encoding APP in these tissues is identical to that expressed in brain, and we identify a second APP mRNA that encodes an additional internal domain with a sequence characteristic of a Kunitz-type serine protease inhibitor. The alternative APP mRNA is present in both brain and peripheral tissues of normal individuals and those with Alzheimer's disease, but its pattern of expression differs from that of the previously reported APP mRNA.
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
March 1990,
Biochemical and biophysical research communications,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
January 1992,
Journal of neuropathology and experimental neurology,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
October 1990,
Biochemistry,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
December 1989,
Journal of molecular graphics,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
March 2004,
Brain research. Molecular brain research,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
January 1991,
Proteins,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
December 1992,
Experimental neurology,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
January 2010,
Bioorganicheskaia khimiia,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
February 1988,
Nature,
R E Tanzi, and
A I McClatchey, and
E D Lamperti, and
L Villa-Komaroff, and
J F Gusella, and
R L Neve
January 1990,
Journal of molecular neuroscience : MN,
